diff --git a/Dockerfile b/Dockerfile
index e8e3ea37c4..98c45eaef1 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -19,6 +19,8 @@ ENV GYP_DEFINES='clang=0 use_experimental_allocator_shim=0 use_allocator=none mu
 # by default. Disable python3 explicitly for now.
 # See https://github.com/google/shaka-packager/issues/763 for details.
 ENV GCLIENT_PY3=0
+# Bypass VPYTHON included by depot_tools, which no longer works in Alpine.
+ENV VPYTHON_BYPASS="manually managed python not supported by chrome operations"
 
 # Build shaka-packager
 WORKDIR shaka_packager
diff --git a/packager/testing/dockers/Alpine_Dockerfile b/packager/testing/dockers/Alpine_Dockerfile
index 5a0aa2b3f8..5e245661b6 100644
--- a/packager/testing/dockers/Alpine_Dockerfile
+++ b/packager/testing/dockers/Alpine_Dockerfile
@@ -20,6 +20,8 @@ ENV GYP_DEFINES='clang=0 use_experimental_allocator_shim=0 use_allocator=none mu
 # by default. Disable python3 explicitly for now.
 # See https://github.com/google/shaka-packager/issues/763 for details.
 ENV GCLIENT_PY3=0
+# Bypass VPYTHON included by depot_tools, which no longer works in Alpine.
+ENV VPYTHON_BYPASS="manually managed python not supported by chrome operations"
 
 # Build and run this docker by mapping shaka-packager with
 # -v "shaka-packager:/shaka-packager".